| http://purl.uniprot.org/citations/26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26114879 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice lacking DNase II display a polyarthritis-like disease phenotype that is driven by translocation of self-DNA into the cytoplasm of phagocytic cells, where it is sensed by pattern recognition receptors. While pro-inflammatory gene expression is non-redundantly linked to the presence of STING in these mice, the contribution of the inflammasome pathway has not been explored. To this end, we studied the role of the DNA-sensing inflammasome receptor AIM2 in this self-DNA driven disease model. Arthritis-prone mice lacking AIM2 displayed strongly decreased signs of joint inflammation and associated histopathological findings. This was paralleled with a reduction of caspase-1 activation and pro-inflammatory cytokine production in diseased joints. Interestingly, systemic signs of inflammation that are associated with the lack of DNase II were not dependent on AIM2. Taken together, these data suggest a tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition."xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0131702"xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/author | "Jakobs C."xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/author | "Perner S."xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/pages | "e0131702"xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/title | "AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis."xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26114879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26114879 |
| http://purl.uniprot.org/citations/26114879 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26114879 |
| http://purl.uniprot.org/uniprot/#_D3Z5U3-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_P56542-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_E9PWM1-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_D3Z341-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_D3Z512-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_G3UZ36-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_I3QI32-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_P33896-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |
| http://purl.uniprot.org/uniprot/#_Q3UFX4-mappedCitation-26114879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26114879 |