| http://purl.uniprot.org/citations/26115623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26115623 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies have shown that LPS-preconditioned tolerant state could protect against brain injury to subsequent challenges. We hypothesized astrocytes were directly involved in the readjustment to confer neuroprotective effects with LPS pretreatment. High-mobility group box 1(HMGB-1) from LPS-preconditioned astrocytes, presumably serving as a positive regulator, might contribute to the favorable preconditioned effects. Furthermore, a potential cellular pathway (PI3K/AKT pathway), has been proposed for the active regulation of LPS-primed reactive astrocytes to secrete HMGB-1. In the present study, we used a low concentration of LPS to directly prime the astrocytes in vitro, and the subsequent astrocytic reactions, including cytokine secretion, the expression of transcription factors, and the release of HMGB-1 were examined after the blockade of the PI3K pathway. The data showed that LPS preconditioning could reduce some capacity of astrocytes to subsequent challenge in vitro. PI3K/AKT pathway was partially involved in the modulation of the release HMGB-1 from reactive astrocytes. These findings offer direct evidence supporting the flexible roles of astrocytes in mediating LPS-primed neuroprotection, and highlight additional targets for future attempts to modify the protective effects of astrocytes through LPS preconditioning."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10571-015-0223-5"xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/author | "Li K.S."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/author | "Xin G."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/author | "Xu Y.X."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/author | "Xie Z.F."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/name | "Cell Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/pages | "93-102"xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/title | "LPS-Primed Release of HMGB-1 from Cortical Astrocytes is Modulated Through PI3K/AKT Pathway."xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/26115623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26115623 |
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