| http://purl.uniprot.org/citations/26118689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26118689 | http://www.w3.org/2000/01/rdf-schema#comment | "The structural features of MUC1-like glycopeptides bearing the Tn antigen (α-O-GalNAc-Ser/Thr) in complex with an anti MUC-1 antibody are reported at atomic resolution. For the α-O-GalNAc-Ser derivative, the glycosidic linkage adopts a high-energy conformation, barely populated in the free state. This unusual structure (also observed in an α-S-GalNAc-Cys mimic) is stabilized by hydrogen bonds between the peptidic fragment and the sugar. The selection of a particular peptide structure by the antibody is thus propagated to the carbohydrate through carbohydrate/peptide contacts, which force a change in the orientation of the sugar moiety. This seems to be unfeasible in the α-O-GalNAc-Thr glycopeptide owing to the more limited flexibility of the side chain imposed by the methyl group. Our data demonstrate the non-equivalence of Ser and Thr O-glycosylation points in molecular recognition processes. These features provide insight into the occurrence in nature of the APDTRP epitope for anti-MUC1 antibodies."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.org/dc/terms/identifier | "doi:10.1002/anie.201502813"xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Jimenez-Barbero J."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Asensio J.L."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Corzana F."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Hurtado-Guerrero R."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Companon I."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Bernardes G.J."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Peregrina J.M."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Valero-Gonzalez J."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Castro-Lopez J."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Salvado M."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Avenoza A."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Busto J.H."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Madariaga D."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Martinez-Saez N."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/author | "Somovilla V.J."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/name | "Angew Chem Int Ed Engl"xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/pages | "9830-9834"xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/title | "Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody."xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/26118689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26118689 |
| http://purl.uniprot.org/citations/26118689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26118689 |