| http://purl.uniprot.org/citations/26119340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26119340 | http://www.w3.org/2000/01/rdf-schema#comment | "Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced insulin/IGF-1 (IIS) signaling. Moreover, direct reduction of Ras or Erk activity leads to increased lifespan. We identify the E-twenty six (ETS) transcriptional repressor, Anterior open (Aop), as central to lifespan extension caused by reduced IIS or Ras attenuation. Importantly, we demonstrate that adult-onset administration of the drug trametinib, a highly specific inhibitor of Ras-Erk-ETS signaling, can extend lifespan. This discovery of the Ras-Erk-ETS pathway as a pharmacological target for animal aging, together with the high degree of evolutionary conservation of the pathway, suggests that inhibition of Ras-Erk-ETS signaling may provide an effective target for anti-aging interventions in mammals."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.06.023"xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Partridge L."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Alic N."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Slack C."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Cabecinha M."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Foley A."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/author | "Hoddinott M.P."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/pages | "72-83"xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/title | "The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity."xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/26119340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26119340 |
| http://purl.uniprot.org/citations/26119340 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26119340 |
| http://purl.uniprot.org/uniprot/Q24324#attribution-34D1EF1D100B24D8C0951B847DFFA0C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/Q24324#attribution-E09B812BDD37573565A5EAABF0E0AACA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/P40417#attribution-34D1EF1D100B24D8C0951B847DFFA0C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/P40417#attribution-E09B812BDD37573565A5EAABF0E0AACA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/Q08012#attribution-DA10858ADE7B1CC5BA6719D2BB5F852B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/Q9XTN2#attribution-34D1EF1D100B24D8C0951B847DFFA0C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/Q01842#attribution-34D1EF1D100B24D8C0951B847DFFA0C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/P08646#attribution-34D1EF1D100B24D8C0951B847DFFA0C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26119340 |
| http://purl.uniprot.org/uniprot/#_Q08012-mappedCitation-26119340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26119340 |