| http://purl.uniprot.org/citations/26120032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26120032 | http://www.w3.org/2000/01/rdf-schema#comment | "Hedgehog (Hh) signaling plays essential roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and cancers. Regulation of the ubiquitin/proteasome-mediated proteolysis of Ci/Gli transcription factors is central to Hh signaling, but whether deubiquitinase is involved in this process remains unknown. Here, we show that Hh stimulates the binding of a ubiquitin-specific protease Usp7 to Ci, which positively regulates Hh signaling activity through inhibiting Ci ubiquitination and degradation mediated by both Slimb-Cul1 and Hib-Cul3 E3 ligases. Furthermore, we find that Usp7 forms a complex with GMP-synthetase (GMPS) to promote Hh pathway activity. Finally, we show that the mammalian counterpart of Usp7, HAUSP, positively regulates Hh signaling by modulating Gli ubiquitination and stability. Our findings reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.05.016"xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/pages | "58-72"xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/title | "Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling."xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/26120032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26120032 |
| http://purl.uniprot.org/citations/26120032 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26120032 |
| http://purl.uniprot.org/uniprot/Q24311#attribution-0C273E771E2201008CDA3BBFC15BE1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q9VFP2#attribution-0C273E771E2201008CDA3BBFC15BE1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q9VFP2#attribution-6C7007621C3AB7E93E4BC94525621F9A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q9VYQ8#attribution-0C273E771E2201008CDA3BBFC15BE1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q9VYQ8#attribution-6C7007621C3AB7E93E4BC94525621F9A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q9VIE7#attribution-6C7007621C3AB7E93E4BC94525621F9A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |
| http://purl.uniprot.org/uniprot/Q8IP45#attribution-0C273E771E2201008CDA3BBFC15BE1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26120032 |