| http://purl.uniprot.org/citations/26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26120033 | http://www.w3.org/2000/01/rdf-schema#comment | "In many adult tissues, homeostasis relies on self-renewing stem cells that are primed for differentiation. The reconciliation mechanisms of these characteristics remain a fundamental question in stem cell biology. We propose that regulation at the post-transcriptional level is essential for homeostasis in murine spermatogonial stem cells (SSCs). Here, we show that Nanos2, an evolutionarily conserved RNA-binding protein, works with other cellular messenger ribonucleoprotein (mRNP) components to ensure the primitive status of SSCs through a dual mechanism that involves (1) direct recruitment and translational repression of genes that promote spermatogonial differentiation and (2) repression of the target of rapamycin complex 1 (mTORC1), a well-known negative pathway for SSC self-renewal, by sequestration of the core factor mTOR in mRNPs. This mechanism links mRNA turnover to mTORC1 signaling through Nanos2-containing mRNPs and establishes a post-transcriptional buffering system to facilitate SSC homeostasis in the fluctuating environment within the seminiferous tubule."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.05.014"xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Hasegawa K."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Saga Y."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Shirakawa T."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Ohbo K."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Saba R."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/author | "Sada A."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/pages | "96-107"xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/title | "RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells."xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/26120033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26120033 |
| http://purl.uniprot.org/citations/26120033 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26120033 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQJ3-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU54-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST40-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUX8-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_A0A286YDC8-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_D3YYS4-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |
| http://purl.uniprot.org/uniprot/#_P70661-mappedCitation-26120033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26120033 |