| http://purl.uniprot.org/citations/26126176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26126176 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed retina. Moreover, a greater percentage of Treg cells in the dLN and retina of Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8 treatment blunted production of inflammatory cytokines by retinal T helper type (TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or function was specific for tissues undergoing an active immune response, as Gal-8 treatment had no effect on T cell populations in the spleen. Given the need for rational therapies for managing human uveitis, Gal-8 emerges as an attractive therapeutic candidate not only for treating retinal autoimmune diseases, but also for other TH1- and TH17-mediated inflammatory disorders."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0130772"xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Hasegawa E."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Chen W.S."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Rabinovich G.A."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Connor K.M."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Panjwani N."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Suryawanshi A."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Sampson J.F."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/author | "Mulki L."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/pages | "e0130772"xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/title | "Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response."xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26126176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26126176 |
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