| http://purl.uniprot.org/citations/26126266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26126266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26126266 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain controversial. In this study, we demonstrate that FZDRs activate G proteins and trigger non-canonical Wnt signaling via the Dishevelled-binding protein, Daple. Daple contains a Gα-binding and activating (GBA) motif, which activates Gαi proteins and an adjacent domain that directly binds FZDRs, thereby linking Wnt stimulation to G protein activation. This triggers non-canonical Wnt responses, that is, suppresses the β-catenin/TCF/LEF pathway and tumorigenesis, but enhances PI3K-Akt and Rac1 signals and tumor cell invasiveness. In colorectal cancers, Daple is suppressed during adenoma-to-carcinoma transformation and expressed later in metastasized tumor cells. Thus, Daple activates Gαi and enhances non-canonical Wnt signaling by FZDRs, and its dysregulation can impact both tumor initiation and progression to metastasis."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07091"xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07091"xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Ghosh P."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Ghosh P."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Janssen K.P."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Janssen K.P."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Goel A."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Goel A."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Murray F."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Murray F."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Willert K."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Willert K."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Marivin A."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Marivin A."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Abal M."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Abal M."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Aznar N."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Aznar N."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Barbazan J."xsd:string |
| http://purl.uniprot.org/citations/26126266 | http://purl.uniprot.org/core/author | "Barbazan J."xsd:string |