| http://purl.uniprot.org/citations/26134396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26134396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26134396 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP13A2 is a lysosomal P-type transport ATPase that has been implicated in Kufor-Rakeb syndrome and Parkinson's disease (PD), providing protection against α-synuclein, Mn(2+), and Zn(2+) toxicity in various model systems. So far, the molecular function and regulation of ATP13A2 remains undetermined. Here, we demonstrate that ATP13A2 contains a unique N-terminal hydrophobic extension that lies on the cytosolic membrane surface of the lysosome, where it interacts with the lysosomal signaling lipids phosphatidic acid (PA) and phosphatidylinositol(3,5)bisphosphate [PI(3,5)P2]. We further demonstrate that ATP13A2 accumulates in an inactive autophosphorylated state and that PA and PI(3,5)P2 stimulate the autophosphorylation of ATP13A2. In a cellular model of PD, only catalytically active ATP13A2 offers cellular protection against rotenone-induced mitochondrial stress, which relies on the availability of PA and PI(3,5)P2. Thus, the N-terminal binding of PA and PI(3,5)P2 emerges as a key to unlock the activity of ATP13A2, which may offer a therapeutic strategy to activate ATP13A2 and thereby reduce α-synuclein toxicity or mitochondrial stress in PD or related disorders."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1508220112"xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1508220112"xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Wuytack F."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Wuytack F."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Palmgren M."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Palmgren M."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Baekelandt V."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Baekelandt V."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Eggermont J."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Eggermont J."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Van den Haute C."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Van den Haute C."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Vangheluwe P."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Vangheluwe P."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "van Veen S."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "van Veen S."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Agostinis P."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Agostinis P."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Guenther Pomorski T."xsd:string |
| http://purl.uniprot.org/citations/26134396 | http://purl.uniprot.org/core/author | "Guenther Pomorski T."xsd:string |