| http://purl.uniprot.org/citations/26145171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26145171 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor BRCA2 is thought to facilitate the handoff of ssDNA from replication protein A (RPA) to the RAD51 recombinase during DNA break and replication fork repair by homologous recombination. However, we find that RPA-RAD51 exchange requires the BRCA2 partner DSS1. Biochemical, structural, and in vivo analyses reveal that DSS1 allows the BRCA2-DSS1 complex to physically and functionally interact with RPA. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for ssDNA. A mutation in the solvent-exposed acidic domain of DSS1 compromises the efficacy of RPA-RAD51 exchange. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression. Our findings may provide a paradigm for understanding the roles of DSS1 in other biological processes."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.05.032"xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Jensen R.B."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Chazin W.J."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Wiese C."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Kwon Y."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "San Filippo J."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Vaithiyalingam S."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Leung S.G."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Maranon D.G."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Fontenay G.V."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/author | "Jimenez-Sainz J."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/pages | "176-187"xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/title | "Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry."xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/26145171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26145171 |
| http://purl.uniprot.org/citations/26145171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26145171 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TMZ9-mappedCitation-26145171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26145171 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TN25-mappedCitation-26145171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26145171 |