| http://purl.uniprot.org/citations/26147228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26147228 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathogenesis of inflammatory skin diseases such as psoriasis involves the release of numerous proinflammatory cytokines, including members of the IL-1 family. Here we report overexpression of IL-1α, IL-1β, and IL-1 receptor antagonist mRNA, associated to expression of IL-23p19, IL-17A, and IL-22 in skin cells, upon topical application of the TLR7 agonist imiquimod (IMQ) in C57BL/6J mice. IMQ-induced skin inflammation was partially reduced in mice deficient for both IL-1α/IL-1β or for IL-1 receptor type 1 (IL-1R1), but not in IL-1α- or IL-1β-deficient mice, demonstrating the redundant activity of IL-1α and IL-1β for skin inflammation. NLRP3 or apoptosis-associated Speck-like protein containing a Caspase recruitment domain-deficient mice had no significant reduction of skin inflammation in response to IMQ treatment, mainly due to the redundancy of IL-1α. However, IMQ-induced skin inflammation was abolished in the absence of MyD88, the adaptor protein shared by IL-1R and TLR signaling pathways. These results are consistent with the TLR7 dependence of IMQ-induced skin inflammation. Thus, IL-1R1 contributes to the IMQ-induced skin inflammation, and disruption of MyD88 signaling completely abrogates this response."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201445215"xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Morel F."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Ryffel B."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Togbe D."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Bernard F.X."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Lecron J.C."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Frouin E."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Favot L."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Vasseur P."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Petit-Paris I."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Blanchard F."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Jegou J.F."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Rabeony H."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Boutet M.A."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/author | "Pohin M."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/pages | "2847-2857"xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/title | "IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome."xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/26147228 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26147228 |
| http://purl.uniprot.org/citations/26147228 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26147228 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-26147228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26147228 |