| http://purl.uniprot.org/citations/26148048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26148048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26148048 | http://www.w3.org/2000/01/rdf-schema#comment | "The glycans displayed on mammalian cells can differ markedly from those on microbes. Such differences could, in principle, be 'read' by carbohydrate-binding proteins, or lectins. We used glycan microarrays to show that human intelectin-1 (hIntL-1) does not bind known human glycan epitopes but does interact with multiple glycan epitopes found exclusively on microbes: β-linked D-galactofuranose (β-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). The 1.6-Å-resolution crystal structure of hIntL-1 complexed with β-Galf revealed that hIntL-1 uses a bound calcium ion to coordinate terminal exocyclic 1,2-diols. N-acetylneuraminic acid (Neu5Ac), a sialic acid widespread in human glycans, has an exocyclic 1,2-diol but does not bind hIntL-1, probably owing to unfavorable steric and electronic effects. hIntL-1 marks only Streptococcus pneumoniae serotypes that display surface glycans with terminal 1,2-diol groups. This ligand selectivity suggests that hIntL-1 functions in microbial surveillance."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3053"xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3053"xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Smith D.F."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Smith D.F."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Wangkanont K."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Wangkanont K."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Cummings R.D."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Cummings R.D."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "McBride R."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "McBride R."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Paulson J.C."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Paulson J.C."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Forest K.T."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Forest K.T."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Kiessling L.L."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Kiessling L.L."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Splain R.A."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Splain R.A."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Wesener D.A."xsd:string |
| http://purl.uniprot.org/citations/26148048 | http://purl.uniprot.org/core/author | "Wesener D.A."xsd:string |