| http://purl.uniprot.org/citations/26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26149475 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesROS1 rearrangement has been found in a subset of lung cancer and ROS1-rearranged tumors are sensitive to ALK kinase inhibitors. This study sought to evaluate the clinicopathological implications and histomorphological characteristics of ROS1-rearranged tumors, especially micropapillary and aerogenous spread growth and to investigate the usefulness of ROS1 immunohistochemistry as a diagnostic test for ROS1 rearrangement.Materials and methodsROS1 rearrangement characterizations by fluorescence in situ hybridization and ROS1 protein and E-cadherin expression by immunohistochemistry were performed using 754 non-small cell lung cancer surgical specimens.ResultsROS1 rearrangement was identified in 10 samples. Histologically, all 10 ROS1-rearranged tumors harbored an adenocarcinoma component. Significantly, we noted a high association between ROS1 rearrangement with a micropapillary component (p<0.001), aerogenous spread (p=0.002), and E-cadherin loss (p=0.049). Survival analysis showed that ROS1 rearrangement was significantly associated with a higher risk of tumor recurrence (p=0.024). The best criterion to detect ROS1-rearrangement by immunohistochemistry was an H-score of ≥100, with a sensitivity and specificity of 90% and 93.5%, respectively.ConclusionsROS1-rearranged adenocarcinoma exhibited distinct morphological and clinicopathological features. Decreased membranous E-cadherin expression and aerogenous spread may be associated with worse disease-free survival. ROS1 immunohistochemistry correlated well with ROS1 gene rearrangement."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lungcan.2015.06.012"xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Park E."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Kim G."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Chung J.H."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Lee C.T."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/author | "Sun P.L."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/name | "Lung Cancer"xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/pages | "343-349"xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/title | "Frequent aerogenous spread with decreased E-cadherin expression of ROS1-rearranged lung cancer predicts poor disease-free survival."xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/26149475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26149475 |
| http://purl.uniprot.org/citations/26149475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26149475 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26149475 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26149475 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26149475 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26149475 |
| http://purl.uniprot.org/uniprot/#_A0A6C0N5X1-mappedCitation-26149475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26149475 |