DESCRIBE <http://purl.uniprot.org/citations/26149693>

Subject	Predicate	Object
http://purl.uniprot.org/citations/26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26149693	http://www.w3.org/2000/01/rdf-schema#comment	" Objective and design Adipose tissue macrophages (ATMs) have been implicated in a number of obesity-related diseases. Because the activated macrophages associated with many types of autoimmune and inflammatory diseases express a folate receptor (FR) that can be exploited for FR-targeted drug delivery, we examined the visceral adipose tissue of obese mice and humans to determine whether ATMs also express FR that are accessible by folate conjugates. Material or subjects C57BL/6 or FATSO mice fed on either a low- or high-fat diet were used in murine studies. Human adipose tissue were obtained from healthy volunteers during adipose reduction surgery. Methods Visceral adipose tissue was collected from both obese mice and humans, collagenase digested, and stained with folate-Oregon Green and antibodies for macrophage markers including F4/80, mannose receptor (CD206), CD11b, and CD11c. Cells were then examined for expression of the above markers by flow cytometry. Furthermore, the ability of folate conjugates to target the FR-expressing ATMs in obese mice was evaluated in vivo. Results A subset of the ATMs harvested from obese mice were found to express FR. Subpopulations of ATMs also simultaneously express both pro- and anti-inflammatory markers, and FR is expressed on both subsets. We then demonstrate that FR-expressing ATMs can be targeted with folate-linked fluorescent dyes in vivo. Conclusions FR are expressed on multiple subsets of ATMs and these subsets can be targeted with folate-linked drugs, allowing for the possible development of FR-targeted therapies for obesity-related inflammatory diseases."xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.org/dc/terms/identifier	"doi:10.1007/s00011-015-0849-2"xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/author	"Low P.S."xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/author	"Hansen M.J."xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/author	"Achini Bandara N."xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/date	"2015"xsd:gYear
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/name	"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/pages	"697-706"xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/title	"Folate receptor expression on murine and human adipose tissue macrophages."xsd:string
http://purl.uniprot.org/citations/26149693	http://purl.uniprot.org/core/volume	"64"xsd:string
http://purl.uniprot.org/citations/26149693	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/26149693
http://purl.uniprot.org/citations/26149693	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/26149693
http://purl.uniprot.org/uniprot/#_A0A0R4J1Q2-mappedCitation-26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/#_A1A4B2-mappedCitation-26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/#_P35846-mappedCitation-26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/#_Q9R223-mappedCitation-26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/#_Q8CFX6-mappedCitation-26149693	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/P35846	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/Q8CFX6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/A1A4B2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/Q9R223	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26149693
http://purl.uniprot.org/uniprot/A0A0R4J1Q2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/26149693