| http://purl.uniprot.org/citations/26152465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26152465 | http://www.w3.org/2000/01/rdf-schema#comment | "Dictyostelium discoideum has historically served as a model system for cell and developmental biology, but recently it has gained increasing attention as a model for the study of human diseases. The extracellular matrix (ECM) of this eukaryotic microbe serves multiple essential functions during development. It not only provides structural integrity to the moving multicellular pseudoplasmodium, or slug, it also provides components that regulate cell motility and differentiation. An LC/MS/MS analysis of slug ECM revealed the presence of a large number of proteins in two wild-type strains, NC4 and WS380B. GO annotation identified a large number of proteins involved in some form of binding (e.g. protein, polysaccharide, cellulose, carbohydrate, ATP, cAMP, ion, lipid, vitamin), as well as proteins that modulate metabolic processes, cell movement, and multicellular development. In addition, this proteomic analysis identified numerous expected (e.g. EcmA, EcmD, discoidin I, discoidin II), as well as unexpected (e.g. ribosomal and nuclear proteins) components. These topics are discussed in terms of the structure and function of the ECM during the development of this model amoebozoan and their relevance to ongoing biomedical research."xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.org/dc/terms/identifier | "doi:10.1002/pmic.201500143"xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/author | "O'Day D.H."xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/author | "Huber R.J."xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/name | "Proteomics"xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/pages | "3315-3319"xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/title | "Proteomic profiling of the extracellular matrix (slime sheath) of Dictyostelium discoideum."xsd:string |
| http://purl.uniprot.org/citations/26152465 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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