| http://purl.uniprot.org/citations/26159901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26159901 | http://www.w3.org/2000/01/rdf-schema#comment | "Preeclampsia is a serious complication of pregnancy with no medical treatment. It is caused by intermittent placental hypoxia and release of sFlt-1 and soluble endoglin, leading to wide spread maternal endothelial dysfunction and multisystem organ injury. YC-1 is a guanylyl cyclase activator and HIF1α inhibitor developed for use in hypertension and atherosclerosis. We examined whether YC-1 reduces sFlt-1 and sENG secretion and reverses endothelial dysfunction in primary human tissues. YC-1 significantly reduced sFlt-1 and sENG secretion from human umbilical vein endothelial cells, purified primary trophoblast cells and placental explants taken from patients with preterm preeclampsia. This was concordant with reduced HIF1α expression. YC-1 also reversed TNFα induced endothelial dysfunction, including reduced vascular cell adhesion molecule 1 expression and monocyte adhesion to primary endothelial cells. We conclude YC-1 decreases placental production of sFlt-1 and sENG and decreases endothelial dysfunction. It is a novel therapeutic candidate for preeclampsia."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2015.06.033"xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Tong S."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Cannon P."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Hannan N.J."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Kaitu'u-Lino T.J."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Hastie R."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Tuohey L."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/author | "Brownfoot F.C."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/pages | "202-208"xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/title | "YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia."xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://purl.uniprot.org/core/volume | "413"xsd:string |
| http://purl.uniprot.org/citations/26159901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26159901 |
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