| http://purl.uniprot.org/citations/26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26160174 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon growth factor stimulation, PAK1 is recruited to the plasma membrane and activated by a mechanism that requires its phosphorylation at Ser-223 by the protein kinase CK2. However, the upstream signaling molecules that regulate this phosphorylation event are not clearly defined. Here, we demonstrate a major role of the CK2α-interacting protein CKIP-1 in activation of PAK1. CK2α, CKIP-1, and PAK1 are translocated to membrane ruffles in response to the epidermal growth factor (EGF), where CKIP-1 mediates the interaction between CK2α and PAK1 in a PI3K-dependent manner. Consistently, PAK1 mediates phosphorylation and modulation of the activity of p41-Arc, one of its plasma membrane substrate, in a fashion that requires PI3K and CKIP-1. Moreover, CKIP-1 knockdown or PI3K inhibition suppresses PAK1-mediated cell migration and invasion, demonstrating the physiological significance of the PI3K-CKIP-1-CK2-PAK1 signaling pathway. Taken together, these findings identify a novel mechanism for the activation of PAK1 at the plasma membrane, which is critical for cell migration and invasion."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.675124"xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/author | "Shin Y.J."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/author | "Kim Y.B."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/author | "Roy A."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/pages | "21076-21085"xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/title | "The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)."xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/26160174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26160174 |
| http://purl.uniprot.org/citations/26160174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26160174 |
| http://purl.uniprot.org/uniprot/#_A8KAN3-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_B3KNX7-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_B7Z3K0-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_B4DY45-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
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| http://purl.uniprot.org/uniprot/#_B7Z302-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_B5BUH5-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_Q13153-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_Q53GL0-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_P68400-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |
| http://purl.uniprot.org/uniprot/#_Q2I0Y7-mappedCitation-26160174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26160174 |