| http://purl.uniprot.org/citations/26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26161748 | http://www.w3.org/2000/01/rdf-schema#comment | "Lim domain only 2 (LMO2) is a transcriptional co-factor required for angiogenesis and the specification of haematopoietic cells during development. LMO2 is widely expressed within haematopoiesis with the exception of T-cells. Failure to downregulate LMO2 during T-cell maturation leads to leukaemia, thus underlining the critical nature of context-dependent regulation of LMO2 expression. We previously identified a distal regulatory element of LMO2 (element -25) that cooperates with the proximal promoter in directing haematopoietic expression. Here we dissected the functional activity of element -25 and showed it to consist of two modules that conferred independent and cell-type specific activities: a 3' myeloid enhancer and a 5' T-cell repressor. The myeloid enhancer was bound by GATA2 in progenitors and its activity depended on a highly conserved GATA motif, whereas the T-cell repressor moiety of element -25 was bound by the Core Binding Factor in T-cells and its repressive activity depended on a highly conserved RUNT motif. Since the myeloid enhancer and nearby downstream region is recurrently involved in oncogenic translocations, our data suggest that the -25 enhancer region provides an open chromatin environment prone to translocations, which in turn cause aberrant LMO2 expression in T-cells due to the removal of the adjacent T-cell repressor."xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0131577"xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/author | "Bonadies N."xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/author | "Gottgens B."xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/author | "Calero-Nieto F.J."xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/pages | "e0131577"xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/title | "The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity."xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/26161748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26161748 |
| http://purl.uniprot.org/citations/26161748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26161748 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG58-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_A0A6M6RJQ2-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_A0A142LSZ9-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_A0A7D4XPZ8-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_B4DVE5-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_B4DT53-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_Q15344-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_P23769-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_P25791-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_Q2TAM6-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_Q9Y3R8-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |
| http://purl.uniprot.org/uniprot/#_O14814-mappedCitation-26161748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26161748 |