| http://purl.uniprot.org/citations/26163370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26163370 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked by ESC-derived passenger DNA potentially containing mutations. Comparative genomic analysis of 129 and C57BL/6J mouse strains revealed indels and single nucleotide polymorphisms resulting in alternative or aberrant amino acid sequences in 1,084 genes in the 129-strain genome. Annotating these passenger mutations to the reported genetically modified congenic mice that were generated using 129-strain ESCs revealed that nearly all these mice possess multiple passenger mutations potentially influencing the phenotypic outcome. We illustrated this phenotypic interference of 129-derived passenger mutations with several case studies and developed a Me-PaMuFind-It web tool to estimate the number and possible effect of passenger mutations in transgenic mice of interest."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2015.06.011"xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Martens L."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Vuylsteke M."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Choi S.M."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Shestopalov V.I."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Vanden Berghe T."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Libert C."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Hulpiau P."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Perry S.W."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Vandenbroucke R.E."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Van Wonterghem E."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Bruggeman I."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/author | "Divert T."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/pages | "200-209"xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/title | "Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice."xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/26163370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26163370 |
| http://purl.uniprot.org/citations/26163370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26163370 |
| http://purl.uniprot.org/uniprot/#_A2A5K8-mappedCitation-26163370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26163370 |
| http://purl.uniprot.org/uniprot/#_B1PL19-mappedCitation-26163370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26163370 |