| http://purl.uniprot.org/citations/26174226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26174226 | http://www.w3.org/2000/01/rdf-schema#comment | "RU486 (Mifepristone) is known as an antagonist of the progesterone receptor and glucocorticoid receptor. Here, we investigated the mechanism underlying anti-tumor activity of RU486 in renal carcinoma Caki cells. Treatment of Caki cells with RU486 was found to induce several signature ER stress markers; including ER stress-specific XBP1 splicing, and the up-regulation of glucose-regulated protein (GRP)-78 and CCAAT/enhancer-binding protein homologous protein (CHOP) expression. RU486-induced expression of CHOP involves the putative C/EBPδ site within the CHOP promoter region. Using a combination of C/EBPδ cDNA transfection, the luciferase assay with a mutated C/EBPδ binding site and siRNA-mediated C/EBPδ knockdown, we found that the C/EBPδ site is required for RU486-mediated activation of the CHOP promoter. In addition, RU486-induced CHOP expression is down-regulated by inhibition of the p38 MAPK and JNK signaling pathways at the post-translational levels. RU486 dose-dependently induced apoptotic cell death in renal carcinoma cells. Suppression of CHOP expression by CHOP siRNA attenuated RU486-induced apoptosis. Taken together, RU486 induces pro-apoptotic ER stress through the induction of CHOP expression."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.25278"xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/author | "Jang J.H."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/author | "Kwon T.K."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/author | "Min K.J."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/pages | "361-369"xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/title | "RU486 Induces Pro-Apoptotic Endoplasmic Reticulum Stress Through the Induction of CHOP Expression by Enhancing C/EBPdelta Expression in Human Renal Carcinoma Caki Cells."xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/26174226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26174226 |
| http://purl.uniprot.org/citations/26174226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26174226 |
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| http://purl.uniprot.org/uniprot/#_Q53YD1-mappedCitation-26174226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26174226 |
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| http://purl.uniprot.org/uniprot/P49716 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26174226 |
| http://purl.uniprot.org/uniprot/P35638 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26174226 |
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