| http://purl.uniprot.org/citations/26175416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26175416 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases. Clinical assessment revealed that DNA-PKcs is significantly elevated in advanced disease and independently predicts for metastases, recurrence, and reduced overall survival. Further investigation demonstrated that DNA-PKcs in advanced tumors is highly activated, independent of DNA damage indicators. Combined, these findings reveal unexpected DNA-PKcs functions, identify DNA-PKcs as a potent driver of tumor progression and metastases, and nominate DNA-PKcs as a therapeutic target for advanced malignancies."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2015.06.004"xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Wohlschlegel J.A."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Vashisht A.A."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "McNair C."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Dean J.L."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Witte O.N."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Knudsen K.E."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Abate-Shen C."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Feng F.Y."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Gomella L.G."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Graham N.A."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Drake J.M."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Davicioni E."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Sharifi N."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Tomlins S.A."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Snook A.E."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Kothari V."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Graeber T.G."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Jones J.K."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Karnes R.J."xsd:string |
| http://purl.uniprot.org/citations/26175416 | http://purl.uniprot.org/core/author | "Aytes A."xsd:string |