| http://purl.uniprot.org/citations/26177679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26177679 | http://www.w3.org/2000/01/rdf-schema#comment | "The oxytocin (OXT) gene is abundantly and highly selectively expressed in magnocellular neurones (MCNs) of the hypothalamic-neurohypophysial system. Previous DNA sequence deletion studies in vivo have shown that the -216-to -100-bp sequence in the 5'-flanking region of the oxytocin gene was required for its cell-type specific expression in the rat supraoptic nucleus. In the present study, we test the coupled hypotheses that this -216-to -100-bp sequence is responsible for (i) the selective expression of the OXT gene in OXT-MNCs and (ii) its selective repression in vasopressin (AVP)-MCNs. We show that, consistent with hypothesis 1, removal of the -216-to -100-bp sequence from the OXT gene completely eliminates its expression in OXT-MCNs in vivo but, in contrast to the prediction of hypothesis 2, there was no appearance of OXT gene expression in AVP-MCNs. Taken together, these and other data demonstrate that the -216-to -100-bp sequence in the 5'-flanking region of the oxytocin gene contains only an activator of transcription operating in the OXT-MCNs."xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.org/dc/terms/identifier | "doi:10.1111/jne.12299"xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/author | "Gainer H."xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/author | "Fields R.L."xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/name | "J Neuroendocrinol"xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/pages | "702-707"xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/title | "The -216- to -100-bp Sequence in the 5'-Flanking Region of the Oxytocin Gene Contains a Cell-Type Specific Regulatory Element for its Selective Expression in Oxytocin Magnocellular Neurones."xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/26177679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26177679 |
| http://purl.uniprot.org/citations/26177679 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26177679 |
| http://purl.uniprot.org/uniprot/#_A6HQ99-mappedCitation-26177679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26177679 |
| http://purl.uniprot.org/uniprot/#_Q63408-mappedCitation-26177679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26177679 |
| http://purl.uniprot.org/uniprot/#_P01179-mappedCitation-26177679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26177679 |
| http://purl.uniprot.org/uniprot/A6HQ99 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26177679 |
| http://purl.uniprot.org/uniprot/Q63408 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26177679 |
| http://purl.uniprot.org/uniprot/P01179 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26177679 |