| http://purl.uniprot.org/citations/26182416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26182416 | http://www.w3.org/2000/01/rdf-schema#comment | "During neocortical development, neurons undergo polarization, oriented migration, and layer-type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here, we show that the transcription factor Bcl11a regulates polarity and migration of upper layer neurons. Bcl11a-deficient late-born neurons fail to correctly switch from multipolar to bipolar morphology, resulting in impaired radial migration. We show that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription. In vivo gain-of-function and rescue experiments demonstrate that Sema3c is a major downstream effector of Bcl11a required for the cell polarity switch and for the migration of upper layer neurons. Our data uncover a novel Bcl11a/Sema3c-dependent regulatory pathway used by migrating cortical neurons."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2015.06.023"xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Simon R."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Britsch S."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Wiegreffe C."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Strehle M."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Tarabykin V."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Kling C."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Srivatsa S."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/author | "Peschkes K."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/pages | "311-325"xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/title | "Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c."xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/26182416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26182416 |
| http://purl.uniprot.org/citations/26182416 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26182416 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-26182416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26182416 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS95-mappedCitation-26182416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26182416 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUG6-mappedCitation-26182416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26182416 |