| http://purl.uniprot.org/citations/26183061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26183061 | http://www.w3.org/2000/01/rdf-schema#comment | "The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. These processes require the stabilization of MKRN1 via AKT-mediated phosphorylation. In cervical cancer patients with high levels of pAKT and MKRN1 expression, PTEN protein levels are low and correlate with a low 5-year survival rate. Taken together, our results demonstrate that PI3K/AKT signals enforce positive-feedback regulation by suppressing PTEN function."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms8769"xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Ko A."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Chun K.H."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Han H.J."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Chung J.Y."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Hewitt S.M."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/author | "Jeong M.H."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/pages | "7769"xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/title | "PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis."xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26183061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26183061 |
| http://purl.uniprot.org/citations/26183061 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26183061 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-26183061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26183061 |
| http://purl.uniprot.org/uniprot/#_A1L0W6-mappedCitation-26183061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26183061 |
| http://purl.uniprot.org/uniprot/#_B4DM96-mappedCitation-26183061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26183061 |