| http://purl.uniprot.org/citations/26186291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26186291 | http://www.w3.org/2000/01/rdf-schema#comment | "Notwithstanding numerous published structures of RNA Polymerase II (Pol II), structural details of Pol II engaging a complete nucleic acid scaffold have been lacking. Here, we report the structures of TFIIF-stabilized transcribing Pol II complexes, revealing the upstream duplex and full transcription bubble. The upstream duplex lies over a wedge-shaped loop from Rpb2 that engages its minor groove, providing part of the structural framework for DNA tracking during elongation. At the upstream transcription bubble fork, rudder and fork loop 1 residues spatially coordinate strand annealing and the nascent RNA transcript. At the downstream fork, a network of Pol II interactions with the non-template strand forms a rigid domain with the trigger loop (TL), allowing visualization of its open state. Overall, our observations suggest that "open/closed" conformational transitions of the TL may be linked to interactions with the non-template strand, possibly in a synchronized ratcheting manner conducive to polymerase translocation."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.06.034"xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Graham B.W."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Trakselis M.A."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Calero M."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Lin G."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Kaplan C.D."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Spahr H."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Calero G."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Cohen A.E."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Barnes C.O."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Malik I."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Pullara F."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/author | "Brown I.S."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/pages | "258-269"xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/title | "Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble."xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/26186291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26186291 |
| http://purl.uniprot.org/citations/26186291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26186291 |
| http://purl.uniprot.org/uniprot/#_P41895-mappedCitation-26186291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26186291 |
| http://purl.uniprot.org/uniprot/#_P27999-mappedCitation-26186291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26186291 |