| http://purl.uniprot.org/citations/26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26188084 | http://www.w3.org/2000/01/rdf-schema#comment | "Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that the SCL/TAL1 interrupting locus (STIL) protein interacts via its coiled-coil region (STIL-CC) with PLK4 in vivo. STIL-CC is the first identified interaction partner of Polo-box 3 (PB3) of PLK4 and also uses a secondary interaction site in the PLK4 L1 region. Structure determination of free PLK4-PB3 and its STIL-CC complex via NMR and crystallography reveals a novel mode of Polo-box-peptide interaction mimicking coiled-coil formation. In vivo analysis of structure-guided STIL mutants reveals distinct binding modes to PLK4-PB3 and L1, as well as interplay of STIL oligomerization with PLK4 binding. We suggest that the STIL-CC/PLK4 interaction mediates PLK4 activation as well as stabilization of centriolar PLK4 and plays a key role in centriole duplication."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07888"xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Maier T."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Nigg E.A."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Hiller S."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Imseng S."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Sauer E."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Arquint C."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Bohm R."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/author | "Gabryjonczyk A.M."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/title | "STIL binding to Polo-box 3 of PLK4 regulates centriole duplication."xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26188084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26188084 |
| http://purl.uniprot.org/citations/26188084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26188084 |
| http://purl.uniprot.org/uniprot/Q15468#attribution-F1DA08559F86D99891597DCD0E6938DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26188084 |
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| http://purl.uniprot.org/uniprot/#_A0A090BML5-mappedCitation-26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26188084 |
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| http://purl.uniprot.org/uniprot/#_B1AL49-mappedCitation-26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26188084 |
| http://purl.uniprot.org/uniprot/#_B7ZLW5-mappedCitation-26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26188084 |
| http://purl.uniprot.org/uniprot/#_Q15455-mappedCitation-26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26188084 |
| http://purl.uniprot.org/uniprot/#_Q15468-mappedCitation-26188084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26188084 |