DESCRIBE <http://purl.uniprot.org/citations/26189259>

Subject	Predicate	Object
http://purl.uniprot.org/citations/26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26189259	http://www.w3.org/2000/01/rdf-schema#comment	" Purpose of investigation To investigate mRNA expression profiles associated with cervical squamous carcinoma progression and to identify key genes involved in invasion and metastasis of cervical squamous cancer. Materials and methods The authors extracted the mRNA expression profile of eight normal cervical tissues by human whole genome microarray. The main functions of differentially expressed genes were identified by gene ontology (GO) analysis. Gene-networks were established based on bioinformatic approaches. Microarray data of the expressions level of key genes verified by qRT-PCR. Results The authors identified 2036 differentially expressed genes between two groups including 1,282 down-regulated genes and 754 up-regulated genes (p < 0.05, FDR < 0.05). Gene-network revealed that PDGFRA, CAV1, and GJA-1 were critical for cervical cancer invasion and metastasis. Conclusions PDGFRA, CAV1, and GJA-1 were revealed as key node genes for cervical cancer invasion and metastasis. The results may provide new evidences and ideas for early diagnosis and prognosis assessment of cervical cancer."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/author	"Cheng Y."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/author	"Geng L."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/author	"Li Z."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/author	"Ma D."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/author	"Zhang Y."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/date	"2015"xsd:gYear
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/name	"Eur J Gynaecol Oncol"xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/pages	"309-317"xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/title	"Cervical squamous cancer mRNA profiles reveal the key genes of metastasis and invasion."xsd:string
http://purl.uniprot.org/citations/26189259	http://purl.uniprot.org/core/volume	"36"xsd:string
http://purl.uniprot.org/citations/26189259	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/26189259
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http://purl.uniprot.org/uniprot/#_B4DI81-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
http://purl.uniprot.org/uniprot/#_B4DMC9-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
http://purl.uniprot.org/uniprot/#_B4DN47-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
http://purl.uniprot.org/uniprot/#_B4DN50-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
http://purl.uniprot.org/uniprot/#_Q71VB8-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
http://purl.uniprot.org/uniprot/#_P16234-mappedCitation-26189259	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/26189259
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