| http://purl.uniprot.org/citations/26195789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26195789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26195789 | http://www.w3.org/2000/01/rdf-schema#comment | "Four-stranded nucleic acid structures called G-quadruplexes have been associated with important cellular processes, which should require G-quadruplex-protein interaction. However, the structural basis for specific G-quadruplex recognition by proteins has not been understood. The DEAH (Asp-Glu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (also named DHX36 or G4R1) specifically binds to and resolves parallel-stranded G-quadruplexes. Here we identified an 18-amino acid G-quadruplex-binding domain of RHAU and determined the structure of this peptide bound to a parallel DNA G-quadruplex. Our structure explains how RHAU specifically recognizes parallel G-quadruplexes. The peptide covers a terminal guanine base tetrad (G-tetrad), and clamps the G-quadruplex using three-anchor-point electrostatic interactions between three positively charged amino acids and negatively charged phosphate groups. This binding mode is strikingly similar to that of most ligands selected for specific G-quadruplex targeting. Binding to an exposed G-tetrad represents a simple and efficient way to specifically target G-quadruplex structures."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1422605112"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1422605112"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Cheong V.V."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Cheong V.V."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Heddi B."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Heddi B."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Martadinata H."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Martadinata H."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Phan A.T."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/author | "Phan A.T."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/pages | "9608-9613"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/pages | "9608-9613"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/title | "Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/title | "Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex."xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/26195789 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26195789 |
| http://purl.uniprot.org/citations/26195789 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26195789 |