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http://purl.uniprot.org/citations/26198919http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26198919http://www.w3.org/2000/01/rdf-schema#comment"

Background

Epstein-Barr virus (EBV) infection is implicated with multiple sclerosis (MS) risk, exacerbation, and progression. The HLA-DRB1*1501 haplotype is a strong MS risk factor consistently documented in MS populations. There are no studies of EBV infections and HLA-DRB1*1501 haplotype associating with MS from Kuwait where MS prevalence has increased significantly.

Objectives

To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait.

Methods

This is a case-control study involving 141 MS patients and 40 healthy controls. Antibody titers against EBV antigens' viral capsid antigen (VCA) and Epstein-Barr nuclear antigen 1 (EBNA1) were measured using enzyme-linked immunosorbent assays. HLA-DRB1*1501 haplotype assessment was done using rs3135005 TaqMan genotyping assay.

Results

Antibody titers against EBV were significantly elevated in MS patients compared to healthy controls (anti-EBNA1, p=0.008; anti-VCA, p=0.028). MS males had higher antibody titers to EBNA1 than healthy male controls (p=0.005) and female MS patients (p=0.03). HLA-DRB1*1501 haplotype genotypes failed to generate a risk association with MS or EBV antibody titers (p=0.6).

Conclusion

An increased immune response to EBV infection is associated with MS incidence influenced by the type of antigen and sex. HLA-DRB1*1501 haplotype is not associated with MS risk in our Kuwaiti MS cohort."xsd:string
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http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/author"Jacob S."xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/author"Al-Mulla F."xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/author"Al-Temaimi R."xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/author"Alroughani R."xsd:string
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http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/name"J Neuroimmunol"xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/pages"57-61"xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/title"Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait."xsd:string
http://purl.uniprot.org/citations/26198919http://purl.uniprot.org/core/volume"285"xsd:string
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