| http://purl.uniprot.org/citations/26201648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26201648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26201648 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the identification of a novel gene family (named MgCRP-I) encoding short secreted cysteine-rich peptides in the Mediterranean mussel Mytilus galloprovincialis. These peptides display a highly conserved pre-pro region and a hypervariable mature peptide comprising six invariant cysteine residues arranged in three intramolecular disulfide bridges. Although their cysteine pattern is similar to cysteines-rich neurotoxic peptides of distantly related protostomes such as cone snails and arachnids, the different organization of the disulfide bridges observed in synthetic peptides and phylogenetic analyses revealed MgCRP-I as a novel protein family. Genome- and transcriptome-wide searches for orthologous sequences in other bivalve species indicated the unique presence of this gene family in Mytilus spp. Like many antimicrobial peptides and neurotoxins, MgCRP-I peptides are produced as pre-propeptides, usually have a net positive charge and likely derive from similar evolutionary mechanisms, that is, gene duplication and positive selection within the mature peptide region; however, synthetic MgCRP-I peptides did not display significant toxicity in cultured mammalian cells, insecticidal, antimicrobial, or antifungal activities. The functional role of MgCRP-I peptides in mussel physiology still remains puzzling."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.org/dc/terms/identifier | "doi:10.1093/gbe/evv133"xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.org/dc/terms/identifier | "doi:10.1093/gbe/evv133"xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Pallavicini A."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Pallavicini A."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Benincasa M."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Benincasa M."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Venier P."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Venier P."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Puillandre N."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Puillandre N."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Guarnaccia C."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Guarnaccia C."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Gerdol M."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Gerdol M."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "De Moro G."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "De Moro G."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Manfrin C."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Manfrin C."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Giulianini P.G."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Giulianini P.G."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Lucafo M."xsd:string |
| http://purl.uniprot.org/citations/26201648 | http://purl.uniprot.org/core/author | "Lucafo M."xsd:string |