| http://purl.uniprot.org/citations/26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26203636 | http://www.w3.org/2000/01/rdf-schema#comment | "Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neutrophil-rich abscesses within the epidermis, and a mixed inflammatory infiltrate in the dermis. The disease may be caused by missense mutations in the IL-36 receptor antagonist, IL-36Ra. Curiously, the related IL-1Ra has therapeutic effects in some of these latter patients. Here, using an experimental mouse model of psoriasiform skin inflammation, we demonstrate in vivo connections between IL-36 and IL-1 expression. After disease initiation, IL-36α-deficient mice exhibited dramatically diminished skin pathology, including absence of epidermal neutrophils, reduced keratinocyte acanthosis, and less dermal edema. In contrast, IL-36β and IL-36γ knockout mice developed disease indistinguishable from that of wild-type mice. The endogenous IL-36α was not processed through proteolysis. Although IL-36α expression was strongly induced in an IL-1 signaling-dependent manner during disease, expression of IL-1α was also dependent upon IL-36α. Hence, after being upregulated by IL-1α, IL-36α acts through a feedback mechanism to boost IL-1α levels. Analyses of double knockout mice further revealed that IL-36α and IL-1α cooperate to promote psoriasis-like disease. In conclusion, IL-1α and IL-36α form a self-amplifying inflammatory loop in vivo that in patients with insufficient counter regulatory mechanisms may become hyper-engaged and/or chronic."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2015.289"xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/author | "Jensen L.E."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/author | "Milora K.A."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/author | "Dubaz O."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/pages | "2992-3000"xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/title | "Unprocessed Interleukin-36alpha Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1."xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/26203636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26203636 |
| http://purl.uniprot.org/citations/26203636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26203636 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_A0A0G2SSZ4-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_A0A571BF22-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_P70343-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_F6SUE5-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_Q149U6-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_Q32MH0-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_Q3U0Y6-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_Q62161-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |
| http://purl.uniprot.org/uniprot/#_P01582-mappedCitation-26203636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26203636 |