| http://purl.uniprot.org/citations/26207352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26207352 | http://www.w3.org/2000/01/rdf-schema#comment | "Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we recently found that 14-3-3ζ(-/-) mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play a significant role in disease pathogenesis we generated a new congenic strain in the BALB/c background to determine the impact of genetic interactions on the 14-3-3ζ(-/-) phenotype. In addition to replicating defects such as aberrant mossy fibre connectivity and impaired spatial memory, our analysis of 14-3-3ζ(-/-) BALB/c mice identified enlarged lateral ventricles, reduced synaptic density and ectopically positioned pyramidal neurons in all subfields of the hippocampus. In contrast to our previous analyses, 14-3-3ζ(-/-) BALB/c mice lacked locomotor hyperactivity that was underscored by normal levels of the dopamine transporter (DAT) and dopamine signalling. Taken together, our results demonstrate that dysfunction of 14-3-3ζ gives rise to many of the pathological hallmarks associated with the human condition. 14-3-3ζ-deficient BALB/c mice therefore provide a novel model to address the underlying biology of structural defects affecting the hippocampus and ventricle, and cognitive defects such as hippocampal-dependent learning and memory."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep12434"xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Lopez A.F."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Haas M."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "McCarthy P."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Greenberg Z."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Heng J."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Baune B.T."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Jaehne E.J."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Schwarz Q."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Parish C.L."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Ramshaw H.S."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "van den Buuse M."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Camera D."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Saleh E."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/author | "Ratnayake U."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/pages | "12434"xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/title | "14-3-3zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders."xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26207352 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26207352 |
| http://purl.uniprot.org/citations/26207352 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26207352 |