| http://purl.uniprot.org/citations/26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26214036 | http://www.w3.org/2000/01/rdf-schema#comment | "The type 2 deiodinase (D2) activates the prohormone T4 to T3. D2 is expressed in skeletal muscle (SKM), and its global inactivation (GLOB-D2KO mice) reportedly leads to skeletal muscle hypothyroidism and impaired differentiation. Here floxed Dio2 mice were crossed with mice expressing Cre-recombinase under the myosin light chain 1f (cre-MLC) to disrupt D2 expression in the late developmental stages of skeletal myocytes (SKM-D2KO). This led to a loss of approximately 50% in D2 activity in neonatal and adult SKM-D2KO skeletal muscle and about 75% in isolated SKM-D2KO myocytes. To test the impact of Dio2 disruption, we measured soleus T3 content and found it to be normal. We also looked at the expression of T3-responsive genes in skeletal muscle, ie, myosin heavy chain I, α-actin, myosin light chain, tropomyosin, and serca 1 and 2, which was preserved in neonatal SKM-D2KO hindlimb muscles, at a time that coincides with a peak of D2 activity in control animals. In adult soleus the baseline level of D2 activity was about 6-fold lower, and in the SKM-D2KO soleus, the expression of only one of five T3-responsive genes was reduced. Despite this, adult SKM-D2KO animals performed indistinguishably from controls on a treadmill test, running for approximately 16 minutes and reached a speed of about 23 m/min; muscle strength was about 0.3 mN/m·g body weight in SKM-D2KO and control ankle muscles. In conclusion, there are multiple sources of D2 in the mouse SKM, and its role is limited in postnatal skeletal muscle fibers."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2015-1246"xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Gereben B."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Ribeiro M.O."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Bianco A.C."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Fernandes G.W."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Ribeiro M.B."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Fonseca T.L."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Ignacio D.L."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Werneck-de-Castro J.P."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Andrade-Feraud C.M."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/author | "Lartey L.J."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/pages | "3842-3852"xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/title | "Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes."xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/26214036 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26214036 |
| http://purl.uniprot.org/citations/26214036 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26214036 |
| http://purl.uniprot.org/uniprot/#_A0A087WRZ7-mappedCitation-26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26214036 |
| http://purl.uniprot.org/uniprot/#_E0CZ30-mappedCitation-26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26214036 |
| http://purl.uniprot.org/uniprot/#_A2RSK4-mappedCitation-26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26214036 |
| http://purl.uniprot.org/uniprot/#_A0A8Z1S5Q0-mappedCitation-26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26214036 |
| http://purl.uniprot.org/uniprot/#_E9PWG4-mappedCitation-26214036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26214036 |