| http://purl.uniprot.org/citations/26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26215444 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the main responses of invariant natural killer T (iNKT) cells to antigen stimulation is the rapid production of interleukin (IL)-4 and interferon (IFN)-γ cytokines. There is a decline in the function of iNKT cells in chronic hepatitis B (CHB) patients. In this study, we explored the impact of programmed cell death 1 (PD-1), T cell immunoglobulin mucin-3 (Tim-3), and cluster of differentiation 28 (CD28) expression on iNKT cell functions in CHB patients. Flow cytometry was used to test iNKT frequencies and levels of PD-1, Tim-3, CD28, IL-4, and IFN-γ secreted by iNKT cells. An enzyme-linked immunosorbent assay (ELISA) was used to measure IL-4 and IFN-γ secretion upon α-galactosylceramide (α-GalCer) activation ex vivo. We found that the levels of expression of PD-1 and Tim-3 from iNKT cells in CHB patients were significantly higher than in healthy donors (p < 0.05), but there was lower expression of CD28 (p < 0.05) and an impaired capability to produce IL-4 and IFN-γ (p < 0.05). In vitro α-GalCer stimulation upregulated the expression of PD-1(+) iNKT cells (p < 0.05), Tim-3(+) iNKT cells (p < 0.05), and CD28(+) iNKT cells (p < 0.05). In response to combination therapies consisting of α-GalCer and anti-PDL1 monoclonal antibody (mAb) and/or anti-Tim-3 mAbs and/or anti-CD80/anti-CD28 mAbs, IL-4(+) and IFN-γ(+) iNKT cells demonstrated different degrees of growth (p < 0.05). The functional decline of iNKT cells was closely related to the decrease in CD28 expression and the increases of Tim-3 and PD-1. In addition, clinical antiviral treatment with lamivudine could partially restore the immune function of iNKT cells in CHB patients."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00705-015-2539-3"xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/author | "Lei Y."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/author | "Ren H."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/name | "Arch Virol"xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/pages | "2535-2545"xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/title | "Roles of the programmed cell death 1, T cell immunoglobulin mucin-3, and cluster of differentiation 288 pathways in the low reactivity of invariant natural killer T cells after chronic hepatitis B virus infection."xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/26215444 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26215444 |
| http://purl.uniprot.org/citations/26215444 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26215444 |
| http://purl.uniprot.org/uniprot/#_A0A0M3M0G7-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_B4E0L1-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_Q86TL7-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_P10747-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_Q15116-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_Q7Z5I0-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_Q8TDQ0-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/#_Q9UMF3-mappedCitation-26215444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/P10747 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26215444 |
| http://purl.uniprot.org/uniprot/Q7Z5I0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26215444 |