| http://purl.uniprot.org/citations/26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26216893 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic proliferative dermatitis in mice (cpdm) is a spontaneous multiorgan inflammatory disorder with pathological hallmarks similar to atopic dermatitis and psoriasis in humans. Cpdm mice lack expression of SHANK-associated RH domain-interacting protein, an adaptor of the linear ubiquitin assembly complex, which acts in the NF-κB pathway to promote inflammation and protect from apoptosis and necroptosis. Although skin inflammation in cpdm mice is driven by TNF- and RIPK1-induced cell death, the contribution of initiating innate immunity sensors and additional inflammatory pathways remains poorly characterized. In this article, we show that inflammasome signaling, including the expression and activation of the inflammatory caspase-1 and -11 and IL-1 family cytokines, was highly upregulated in the skin of cpdm mice prior to overt disease onset. Genetic ablation of caspase-1 and -11 from cpdm mice significantly reduced skin inflammation and delayed disease onset, whereas systemic immunological disease persisted. Loss of Nlrp3 also attenuated skin disease, albeit more variably. Strikingly, induction of apoptosis and necroptosis effectors was sharply decreased in the absence of caspase-1 and -11. These results position the inflammasome as an important initiating signal in skin disease pathogenesis and provide novel insights about inflammasome and cell death effector cross-talk in the context of inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1500542"xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/author | "Douglas T."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/author | "Champagne C."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/author | "Saleh M."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/author | "Lapointe J.M."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/author | "Morizot A."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/pages | "2365-2373"xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/title | "The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice."xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/26216893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26216893 |
| http://purl.uniprot.org/citations/26216893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26216893 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |
| http://purl.uniprot.org/uniprot/#_E0CZH2-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |
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| http://purl.uniprot.org/uniprot/#_P70343-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |
| http://purl.uniprot.org/uniprot/#_F6SUE5-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |
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| http://purl.uniprot.org/uniprot/#_Q5SXI6-mappedCitation-26216893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26216893 |