| http://purl.uniprot.org/citations/26216936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26216936 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple pathologic conditions, including hemorrhage, tumor angiogenesis, and ischemia-reperfusion events, will result in hypoxia and subsequent reperfusion. Previous studies have analyzed the lipid changes within whole tissues and indicated that ischemia-reperfusion altered tissue and cellular phospholipids. Using an in vitro cell culture model of hypoxia and reoxygenation, we examined the endothelial lipid changes. We hypothesized that phospholipid scramblase 1, a protein that regulates bilayer asymmetry, is involved in altering the phospholipids of endothelial cells during hypoxia, a component of ischemia, leading to β2-glycoprotein I and IgM binding and subsequent lipid-mediated, inflammatory responses. We have completed the first comprehensive study of steady-state phospholipid scramblase 1 mRNA levels, protein expression, and activity under conditions of hypoxia and reoxygenation. Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to β2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.3a1014-480r"xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/author | "Pope M.R."xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/author | "Fleming S.D."xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/author | "Slone E.A."xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/pages | "791-804"xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/title | "Phospholipid scramblase 1 is required for beta2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation."xsd:string |
| http://purl.uniprot.org/citations/26216936 | http://purl.uniprot.org/core/volume | "98"xsd:string |
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