| http://purl.uniprot.org/citations/26217013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26217013 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence indicates that the metalloproteinase Adamts-1 plays a significant role in the pathophysiology of vessel remodeling, but little is known about the signaling pathways that control Adamts-1 expression. We show that vascular endothelial growth factor (VEGF), angiotensin-II, interleukin-1β, and tumor necrosis factor α, stimuli implicated in pathological vascular remodeling, increase Adamts-1 expression in endothelial and vascular smooth muscle cells. Analysis of the intracellular signaling pathways implicated in this process revealed that VEGF and angiotensin-II upregulate Adamts-1 expression via activation of differential signaling pathways that ultimately promote functional binding of the NFAT or C/EBPβ transcription factors, respectively, to the Adamts-1 promoter. Infusion of mice with angiotensin-II triggered phosphorylation and nuclear translocation of C/EBPβ proteins in aortic cells concomitantly with an increase in the expression of Adamts-1, further underscoring the importance of C/EBPβ signaling in angiotensin-II-induced upregulation of Adamts-1. Similarly, VEGF promoted NFAT activation and subsequent Adamts-1 induction in aortic wall in a calcineurin-dependent manner. Our results demonstrate that Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT or C/EBPβ transcription factors. Targeting of these pathways may prove useful in the treatment of vascular disease."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00494-15"xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Armesilla A.L."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Redondo J.M."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Campanero M.R."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Arroyo A.G."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Escolano A."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Alfranca A."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Mendez-Barbero N."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Villahoz S."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Oller J."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Martin-Alonso M."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/author | "Lozano-Vidal N."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/pages | "3409-3422"xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/title | "C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling."xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26217013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26217013 |
| http://purl.uniprot.org/citations/26217013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26217013 |
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| http://purl.uniprot.org/uniprot/#_O70192-mappedCitation-26217013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26217013 |
| http://purl.uniprot.org/uniprot/#_P97857-mappedCitation-26217013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26217013 |