| http://purl.uniprot.org/citations/26219900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26219900 | http://www.w3.org/2000/01/rdf-schema#comment | "Papillary thyroid carcinoma is one of the most common subtypes of thyroid cancer and portends a good prognosis. N-cadherin (neural cadherin) is a member of the classical cadherin family and is often overexpressed in many types of cancers. Snail, a kind of zinc finger protein, is a transcriptional repressor which has been intensively studied in mammals. We investigate the immunohistochemical expression of Snail and N-cadherin in papillary thyroid carcinoma tissues and cells and then discuss the clinical value of Snail and N-cadherin expression. Immunohistochemical technique was performed to detect Snail and N-cadherin in 60 cases of papillary thyroid carcinoma and analyzed the relationship between the expression of Snail, N-cadherin, and clinicopathological indicators. Western blot was used to investigate the constitutive and inducible expression of Snail and N-cadherin. In our study, the expression rate of Snail and N-cadherin was 85.0 % (51/60) and 78.3 % (47/60), respectively, in papillary thyroid carcinoma. The expression rate of Snail and N-cadherin in thyroid papillary carcinoma with metastatic lymph nodes was 93.3 and 86.7 %, respectively, while in papillary thyroid carcinoma tissue without lymph node metastasis, the expression rate was 60.0 and 53.3 %, respectively. The positive correlation of Snail and N-cadherin was observed (r = 0.721, p < 0.01). In addition, Western blot further identified the constitutive and inducible expression of Snail and N-cadherin in papillary thyroid carcinoma tissues and cell lines. In conclusion, Snail and N-cadherin are constitutively and inducibly expressed in papillary thyroid carcinoma and may play important roles in the development and metastasis of papillary thyroid carcinoma. Snail and N-cadherin may be used as an effective indicator."xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-015-3820-5"xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/author | "Shi R."xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/pages | "413-417"xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/title | "Co-expression and clinical utility of Snail and N-cadherin in papillary thyroid carcinoma."xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/26219900 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26219900 |
| http://purl.uniprot.org/citations/26219900 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26219900 |
| http://purl.uniprot.org/uniprot/#_C9J126-mappedCitation-26219900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26219900 |
| http://purl.uniprot.org/uniprot/#_P19022-mappedCitation-26219900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26219900 |
| http://purl.uniprot.org/uniprot/#_O95863-mappedCitation-26219900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26219900 |
| http://purl.uniprot.org/uniprot/P19022 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26219900 |
| http://purl.uniprot.org/uniprot/C9J126 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26219900 |
| http://purl.uniprot.org/uniprot/O95863 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26219900 |