| http://purl.uniprot.org/citations/26220403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26220403 | http://www.w3.org/2000/01/rdf-schema#comment | "The proteins that coordinate complex adipogenic transcriptional networks are poorly understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and transcription factor networks. Here we report that 14-3-3ζ-knockout mice are strikingly lean from birth with specific reductions in visceral fat depots. Conversely, transgenic 14-3-3ζ overexpression potentiates obesity, without exacerbating metabolic complications. Only the 14-3-3ζ isoform is essential for adipogenesis based on isoform-specific RNAi. Mechanistic studies show that 14-3-3ζ depletion promotes autophagy-dependent degradation of C/EBP-δ, preventing induction of the master adipogenic factors, Pparγ and C/EBP-α. Transcriptomic data indicate that 14-3-3ζ acts upstream of hedgehog signalling-dependent upregulation of Cdkn1b/p27(Kip1). Indeed, concomitant knockdown of p27(Kip1) or Gli3 rescues the early block in adipogenesis induced by 14-3-3ζ knockdown in vitro. Adipocyte precursors in 14-3-3ζKO embryos also appear to have greater Gli3 and p27(Kip1) abundance. Together, our in vivo and in vitro findings demonstrate that 14-3-3ζ is a critical upstream driver of adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms8671"xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Acker-Palmer A."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Lopez A.F."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Albrecht T."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Clee S.M."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Nislow C."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Johnson J.D."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Sarai K."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Guthridge M.A."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Lim G.E."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Ramshaw H.S."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Lee J.T.C."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/author | "Piske M."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/pages | "7671"xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/title | "14-3-3zeta coordinates adipogenesis of visceral fat."xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26220403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26220403 |
| http://purl.uniprot.org/citations/26220403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26220403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDD0-mappedCitation-26220403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26220403 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-26220403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26220403 |