| http://purl.uniprot.org/citations/26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26229955 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the study was to determine the effect of H2 relaxin (RLN2) on invasion, migration, and chemosensitivity to cisplatin in human osteosarcoma U2-OS and MG-63 cells and then to investigate the effect of RLN2 on the AKT/NF-κB signaling pathway. The expression of RLN2, p-AKT (Ser473), and p-ERK1/2 (Phospho-Thr202/Tyr204) proteins was detected by western blot in OS tissues from 21 patients with pulmonary metastatic disease, and the correlation between RLN2 and p-AKT or RLN2 and p-ERK1/2 expression was investigated. RLN2 expression was inhibited by RLN2 siRNA transfection in the MG-63 cells. RLN2 was overexpressed in the U2-OS cells by treatment with recombinant relaxin. The results showed that positive relation was found between RLN2 and p-AKT expression in tissues of OS. Silencing RLN2 inhibited cell migratory and invasive ability and angiogenesis formation and increased the chemosensitivity to cisplatin in MG-63 cells. RLN2 overexpression promoted migratory and invasive ability and angiogenesis and increased the chemoresistance to cisplatin in U2-OS cells. Silencing RLN2 inhibited the activity of AKT/NF-κB signaling pathway in MG-63 cells, and vice versa. Blockage of both pathways by specific inhibitors abrogated RLN2-induced survival and invasion of OS cells, and vice versa. Our results indicated RLN2 confers to migratory and invasive ability, angiogenesis, and chemoresistance to cisplatin via modulating the AKT/NF-κB signaling pathway in vitro."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.org/dc/terms/identifier | "doi:10.1155/2015/147468"xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/author | "Han Z."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/author | "Yue B."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/pages | "147468"xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/title | "RLN2 Is a Positive Regulator of AKT-2-Induced Gene Expression Required for Osteosarcoma Cells Invasion and Chemoresistance."xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://purl.uniprot.org/core/volume | "2015"xsd:string |
| http://purl.uniprot.org/citations/26229955 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26229955 |
| http://purl.uniprot.org/citations/26229955 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26229955 |
| http://purl.uniprot.org/uniprot/#_A0A0U4CQG9-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_B4DG79-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_B3KP61-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_B7Z8Z9-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_P04090-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_P31751-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_Q6P4H3-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/#_Q8TBE2-mappedCitation-26229955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/B4DG79 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26229955 |
| http://purl.uniprot.org/uniprot/P04090 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26229955 |