| http://purl.uniprot.org/citations/26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26231041 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes independently of Tel1/ATM and Mec1/ATR. Since the DSB ends undergo nucleolytic degradation (resection) of their 5'-ending strands, we investigated the contribution of resection in this DSB-induced transcriptional inhibition. We discovered that resection-defective mutants fail to stop transcription around a DSB, and the extent of this failure correlates with the severity of the resection defect. Furthermore, Rad9 and generation of γH2A reduce this DSB-induced transcriptional inhibition by counteracting DSB resection. Therefore, the conversion of the DSB ends from double-stranded to single-stranded DNA, which is necessary to initiate DSB repair by homologous recombination, is responsible for loss of transcription around a DSB in S. cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.08942"xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Wery M."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "d'Adda di Fagagna F."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Clerici M."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Longhese M.P."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Colombo C.V."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Manfrini N."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Morillon A."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/author | "Descrimes M."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/title | "Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26231041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26231041 |
| http://purl.uniprot.org/citations/26231041 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26231041 |
| http://purl.uniprot.org/uniprot/#_P25300-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P08518-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P23255-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P38110-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P38111-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P39875-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P0CY11-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |
| http://purl.uniprot.org/uniprot/#_P0CY13-mappedCitation-26231041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26231041 |