| http://purl.uniprot.org/citations/26237449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26237449 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Jun is a proto-oncoprotein that is commonly overexpressed in many types of cancer and is believed to regulate cell proliferation, the cell cycle, and apoptosis by controlling AP-1 activity. Understanding the c-Jun regulation is important to develop treatment strategy for cancer. The COP9 signalosome subunit 6 (CSN6) plays a critical role in ubiquitin-mediated protein degradation. MEKK1 is a serine/threonine kinase and E3 ligase containing PHD/RING domain involved in c-Jun ubiquitination. Here, we show that CSN6 associates with MEKK1 and reduces MEKK1 expression level by facilitating the ubiquitin-mediated degradation of MEKK1. Also we show that CSN6 overexpression diminishes MEKK1-mediated c-Jun ubiquitination, which is manifested in mitigating osmotic stress-mediated c-Jun downregulation. Thus, CSN6 is involved in positively regulating the stability of c-Jun. Overexpression of CSN6 correlates with the upregulation of c-Jun target gene expression in cancer. These findings provide new insight into CSN6-MEKK1-c-Jun axis in tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2015.1078030"xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/author | "Lee M.H."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/author | "Phan L."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/pages | "3079-3087"xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/title | "CSN6 positively regulates c-Jun in a MEKK1-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/26237449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26237449 |
| http://purl.uniprot.org/citations/26237449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26237449 |
| http://purl.uniprot.org/uniprot/#_B4DHR8-mappedCitation-26237449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26237449 |
| http://purl.uniprot.org/uniprot/#_B2R514-mappedCitation-26237449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26237449 |
| http://purl.uniprot.org/uniprot/#_Q7L5N1-mappedCitation-26237449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26237449 |
| http://purl.uniprot.org/uniprot/Q7L5N1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26237449 |
| http://purl.uniprot.org/uniprot/B4DHR8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26237449 |
| http://purl.uniprot.org/uniprot/B2R514 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26237449 |