| http://purl.uniprot.org/citations/26241055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26241055 | http://www.w3.org/2000/01/rdf-schema#comment | "Due to their ability to rapidly proliferate and produce effector cytokines, memory CD8+ T cells increase protection following reexposure to a pathogen. However, low inflammatory immunizations do not provide memory CD8+ T cells with a proliferation advantage over naive CD8+ T cells, suggesting that cell-extrinsic factors enhance memory CD8+ T cell proliferation in vivo. Herein, we demonstrate that inflammatory signals are critical for the rapid proliferation of memory CD8+ T cells following infection. Using murine models of viral infection and antigen exposure, we found that type I IFN-driven expression of IL-15 in response to viral infection prepares memory CD8+ T cells for rapid division independently of antigen reexposure by transiently inducing cell-cycle progression via a pathway dependent on mTOR complex-1 (mTORC1). Moreover, exposure to IL-15 allowed more rapid division of memory CD8+ T cells following antigen encounter and enhanced their protective capacity against viral infection. Together, these data reveal that inflammatory IL-15 promotes optimal responses by memory CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci81261"xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Harty J.T."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Varga S.M."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Hancox L.S."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Richer M.J."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Hartwig S.M."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/author | "Pewe L.L."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/pages | "3477-3490"xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/title | "Inflammatory IL-15 is required for optimal memory T cell responses."xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/26241055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26241055 |
| http://purl.uniprot.org/citations/26241055 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26241055 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-26241055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26241055 |
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