| http://purl.uniprot.org/citations/26247728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26247728 | http://www.w3.org/2000/01/rdf-schema#comment | "Excessive N-methyl-D-aspartate receptor (NMDAR) activation and the resulting activation of neuronal nitric oxide synthase (nNOS) cause neuronal injury. Homer1b/c facilitates NMDAR-PSD95-nNOS complex interactions, and Homer1a is a negative competitor of Homer1b/c. We report that Homer1a was both upregulated by and protected against NMDA-induced neuronal injury in vitro and in vivo. The neuroprotective activity of Homer1a was associated with NMDA-induced Ca2+ influx, oxidative stress and the resultant downstream signaling activation. Additionally, we found that Homer1a functionally regulated NMDAR channel properties in neurons, but did not regulate recombinant NR1/NR2B receptors in HEK293 cells. Furthermore, we found that Homer1a detached the physical links among NR2B, PSD95 and nNOS and reduced the membrane distribution of NMDAR. NMDA-induced neuronal injury was more severe in Homer1a homozygous knockout mice (KO, Homer1a-/-) when compared with NMDA-induced neuronal injury in wild-type mice (WT, Homer1a+/+). Additionally, Homer1a overexpression in the cortex of Homer1a-/-mice alleviated NMDA-induced neuronal injury. These findings suggest that Homer1a may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B-PSD95-nNOS complexes and reducing the membrane distribution of NMDARs."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2015.216"xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Han F."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Han H."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Fei Z."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Su N."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Zhang C.'"xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Yao L.B."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Luo P."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Rao W."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/author | "Liu M.D."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/pages | "e1843"xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/title | "Scaffolding protein Homer1a protects against NMDA-induced neuronal injury."xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26247728 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26247728 |
| http://purl.uniprot.org/citations/26247728 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26247728 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEA7-mappedCitation-26247728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26247728 |
| http://purl.uniprot.org/uniprot/#_G3X9V4-mappedCitation-26247728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26247728 |
| http://purl.uniprot.org/uniprot/#_Q62108-mappedCitation-26247728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26247728 |
| http://purl.uniprot.org/uniprot/#_Q01097-mappedCitation-26247728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26247728 |