| http://purl.uniprot.org/citations/26250653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26250653 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeThe aim of this study was to determine whether the brain uptake of [(18)F]Mefway is influenced by the action of P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) in rodents.Procedures[(18)F]Mefway was applied to rats pharmacologically inhibited with tariquidar (TQD) and to genetically disrupted mice.ResultsPretreatment of TQD results in 160% higher hippocampal uptake compared with control rats. In genetically disrupted mice, a maximal brain uptake value of 3.2 SUV in the triple knockout mice (tKO, Mdr1a/b((-/-))Bcrp1((-/-))) was comparable to that of the double knockout mice (dKO, Mdr1a/b((-/-))) and 2-fold those of the wild-type and Bcrp1((-/-)) knockout mice. The differences of binding values were statistically insignificant between control and experimental groups. The brain-to-plasma ratios for tKO mice were also two to five times higher than those for other groups.Conclusions[(18)F]Mefway is modulated by P-gp, and not by Bcrp in rodents."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11307-015-0883-z"xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Lee K.C."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Song J.S."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Kang J.H."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Cho W.K."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Kim K.M."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Bae M.A."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Ryu Y.H."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/author | "Lyoo C.H."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/name | "Mol Imaging Biol"xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/pages | "267-273"xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/title | "P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain."xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/26250653 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26250653 |
| http://purl.uniprot.org/citations/26250653 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26250653 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGL4-mappedCitation-26250653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26250653 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B6-mappedCitation-26250653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26250653 |