| http://purl.uniprot.org/citations/26253029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26253029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26253029 | http://www.w3.org/2000/01/rdf-schema#comment | "The transport of pyruvate into mitochondria requires a specific carrier, the mitochondrial pyruvate carrier (MPC). The MPC represents a central node of carbon metabolism, and its activity is likely to play a key role in bioenergetics. Until now, investigation of the MPC activity has been limited. However, the recent molecular identification of the components of the carrier has allowed us to engineer a genetically encoded biosensor and to monitor the activity of the MPC in real time in a cell population or in a single cell. We report that the MPC activity is low in cancer cells, which mainly rely on glycolysis to generate ATP, a characteristic known as the Warburg effect. We show that this low activity can be reversed by increasing the concentration of cytosolic pyruvate, thus increasing oxidative phosphorylation. This biosensor represents a unique tool to investigate carbon metabolism and bioenergetics in various cell types."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.06.035"xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.06.035"xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Zamboni N."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Zamboni N."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Pouyssegur J."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Pouyssegur J."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Martinou J.C."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Martinou J.C."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Vanderperre B."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Vanderperre B."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Pierredon S."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Pierredon S."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Compan V."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Compan V."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Krznar P."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Krznar P."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Marchiq I."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/author | "Marchiq I."xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/26253029 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |