| http://purl.uniprot.org/citations/26254814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26254814 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes mellitus generates metabolic changes associated with inflammatory events that may eventually affect all body tissues. Both high-mobility group box 1 (HMGB1) and β-catenin are active players in inflammation. The study aimed to determine whether HMGB1 modulates the β-catenin activity in supporting inflammation, using an experimental type 1 diabetes mouse model. The protein and gene expression of HMGB1 were significantly increased (2-fold) in the diabetic lung compared to control and were positively correlated with the HMGB1 levels detected in serum. Co-immunoprecipitation of HMGB1 with RAGE co-exists with activation of PI3K/AKT1 and NF-kB signaling pathways. At the same time β-catenin was increased in nuclear fraction (3.5 fold) while it was down-regulated in diabetic plasma membrane (2-fold). There was no difference of β-catenin gene expression between the control and diabetic mice. β-Catenin phosphorylation at Ser552 was higher in diabetic nuclear fraction, suggesting that AKT1 activation promotes β-catenin nuclear translocation. In addition, c-Jun directly binds β-catenin indicating the transcriptional activity of β-catenin in diabetes, sustained by significantly COX2 increase by 6-fold in the cytosolic extract of diabetic lung compared to control. Taken together, the data support the new concept that HMGB1 maintains the inflammation through RAGE/AKT1/β-catenin pathway in the diabetic lung."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2015.07.020"xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/author | "Antohe F."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/author | "Uyy E."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/author | "Boteanu R.M."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/author | "Suica V.I."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/pages | "55-64"xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/title | "High-mobility group box 1 enhances the inflammatory process in diabetic lung."xsd:string |
| http://purl.uniprot.org/citations/26254814 | http://purl.uniprot.org/core/volume | "583"xsd:string |
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