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http://purl.uniprot.org/citations/26262501http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26262501http://www.w3.org/2000/01/rdf-schema#comment"

Background

It is widely accepted that HLA donor-specific antibodies (DSA) are associated with antibody-mediated rejection and graft loss. However, in many transplant programs, preformed anti-HLA-Cw and anti-HLA-DP DSA are not considered in organ allocation policies because their clinical relevance is still uncertain.

Methods

We analyzed the clinical impact of Cw/DP DSA through a retrospective study, comparing 48 patients transplanted with isolated preformed Cw/DP DSA (Cw/DP DSA group) with (i) 104 matched HLA-sensitized kidney transplant recipients with No DSA at D0 (No DSA group) and (ii) 47 kidney transplant recipients with preformed A, -B, -DR, -DQ DSA (A/B/DR/DQ DSA group).

Results

A positive flow cytometry crossmatch in the Cw/DP DSA group was more frequent than in the No DSA group and as frequent as in the A/B/DR/DQDSA group. Two years after transplantation, the biopsy-proven acute rejection-free survival was worse in the Cw/DP and A/B/DR/DQ DSA groups than in the No DSA group (65%, 84%, 93%, P = 0.001 and P = 0.05, respectively). Accordingly, graft survival was lower in the Cw/DP and the A/B/DR/DQ DSA groups than in the No DSA group (87%, 89%, 95%, P = 0.02 and P = 0.1, respectively).

Conclusions

These results suggest that preformed anti-HLA-Cw and anti-HLA-DP DSA are as deleterious as anti-HLA A/B/DR/DQ DSA. It justifies their inclusion in kidney allocation programs and in immunological risk stratification algorithms."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.org/dc/terms/identifier"doi:10.1097/tp.0000000000000821"xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Martinez C."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Congy-Jolivet N."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Kamar N."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Guidicelli G."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Visentin J."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Taupin J.L."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Couzi L."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Merville P."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Rostaing L."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Lepreux S."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Bachelet T."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Del Bello A."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/author"Kejji S."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/name"Transplantation"xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/pages"159-166"xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/title"Deleterious Impact of Donor-Specific Anti-HLA Antibodies Toward HLA-Cw and HLA-DP in Kidney Transplantation."xsd:string
http://purl.uniprot.org/citations/26262501http://purl.uniprot.org/core/volume"100"xsd:string
http://purl.uniprot.org/citations/26262501http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26262501
http://purl.uniprot.org/citations/26262501http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26262501
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-26262501http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26262501
http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-26262501http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26262501
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