| http://purl.uniprot.org/citations/26263979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26263979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26263979 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy and apoptosis share regulatory molecules enabling crosstalk in pathways that affect cellular homeostasis including response to viral infections and survival of tumor cells. Ribonuclease L (RNase L) is an antiviral endonuclease that is activated in virus-infected cells and cleaves viral and cellular single-stranded RNAs to produce small double-stranded RNAs with roles in amplifying host responses. Activation of RNase L induces autophagy and apoptosis in many cell types. However, the mechanism by which RNase L mediates crosstalk between these two pathways remains unclear. Here we show that small dsRNAs produced by RNase L promote a switch from autophagy to apoptosis by caspase-mediated cleavage of Beclin-1, terminating autophagy. The caspase 3-cleaved C-terminal fragment of Beclin-1 enhances apoptosis by translocating to the mitochondria along with proapoptotic protein, Bax, and inducing release of cytochrome C to the cytosol. Cleavage of Beclin-1 determines switch to apoptosis since expression of caspase-resistant Beclin-1 inhibits apoptosis and sustains autophagy. Moreover, inhibiting RNase L-induced autophagy promotes cell death and inhibiting apoptosis prolongs autophagy in a cross-inhibitory mechanism. Our results demonstrate a novel role of RNase L generated small RNAs in cross-talk between autophagy and apoptosis that impacts the fate of cells during viral infections and cancer."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms160817611"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms160817611"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Mukherjee S."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Mukherjee S."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Siddiqui M.A."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Siddiqui M.A."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Malathi K."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Malathi K."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Manivannan P."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/author | "Manivannan P."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/name | "Int. J. Mol. Sci."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/name | "Int. J. Mol. Sci."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/pages | "17611-17636"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/pages | "17611-17636"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/title | "RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of beclin-1."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/title | "RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of beclin-1."xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/26263979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26263979 |
| http://purl.uniprot.org/citations/26263979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26263979 |