| http://purl.uniprot.org/citations/26265085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26265085 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic rejection remains a major obstacle in transplant medicine. Recent studies suggest a crucial role of the chemokine SDF-1 on neointima formation after injury. Here, we investigate the potential therapeutic effect of inhibiting the SDF-1/CXCR4/CXCR7 axis with an anti-SDF-1 Spiegelmer (NOX-A12) on the development of chronic allograft vasculopathy. Heterotopic heart transplants from H-2bm12 to B6 mice and aortic transplants from Balb/c to B6 were performed. Mice were treated with NOX-A12. Control animals received a nonfunctional Spiegelmer (revNOX-A12). Samples were retrieved at different time points and analysed by histology, RT-PCR and proliferation assay. Blockade of SDF-1 caused a significant decrease in neointima formation as measured by intima/media ratio (1.0 ± 0.1 vs. 1.8 ± 0.1, P < 0.001 AoTx; 0.35 ± 0.05 vs. 1.13 ± 0.27, P < 0.05 HTx). In vitro treatment of primary vascular smooth muscle cells with NOX-A12 showed a significant reduction in proliferation (0.42 ± 0.04 vs. 0.24 ± 0.03, P < 0.05). TGF-β, TNF-α and IL-6 levels were significantly reduced under SDF-1 inhibition (3.42 ± 0.37 vs. 1.67 ± 0.33, P < 0.05; 2.18 ± 0.37 vs. 1.0 ± 0.39, P < 0.05; 2.18 ± 0.26 vs. 1.6 ± 0.1, P < 0.05). SDF-1/CXCR4/CXCR7 plays a critical role in the development of chronic allograft vasculopathy (CAV). Therefore, pharmacological inhibition of SDF-1 with NOX-A12 may represent a therapeutic option to ameliorate chronic rejection changes."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.org/dc/terms/identifier | "doi:10.1111/tri.12651"xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Wagner A."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Werner J."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Klussmann S."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Kalnins A."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Guba M."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Fischereder M."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Meiser B."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Andrassy M."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Habicht A."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Rentsch M."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Stangl M."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Bazhin A.V."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Andrassy J."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Pratschke S."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/author | "Thomas M.N."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/name | "Transpl Int"xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/pages | "1426-1435"xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/title | "SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy."xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/26265085 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26265085 |
| http://purl.uniprot.org/citations/26265085 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26265085 |